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Tremor Research Group
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Research

Clinical research and the TETRAS scale

The TRG developed, validated and published TETRAS, and our members have critical roles in most North American clinical trials for essential tremor.

The scale

TETRAS — Essential Tremor Rating Assessment Scale

The rating scale used in essential tremor trials, and how investigators get certified as raters.

Explore TETRAS

For Study Sponsors

Run your essential tremor trial with TRG investigators

The TRG comprises tremor specialists who are investigators with critical roles in the design and implementation of most North American clinical trials for essential tremor over the past 30 years. The TRG can facilitate all aspects of study preparation and conduct. With our validated TETRAS rating scale, we have the critical tool for research in tremor, one that has been used by the most recent essential tremor trials. TETRAS can be licensed, and with it, we can provide various degrees of support, ranging from training, credentialing, scale testing, and expert ratings.

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Publications

Selected publications

  1. Lyons KE, Pahwa R, Comella CL, Eisa MS, Elble RJ, Fahn S, Jankovic J, Juncos JL, Koller WC, Ondo WG, Sethi KD, Stern MB, Tanner CM, Tintner R, Watts RL. Benefits and risks of pharmacological treatments for essential tremor. Drug Saf 2003;26:461-81.
  2. Elble RJ for the Tremor Research Group and Conference Attendees. Report from a U.S. conference on essential tremor. Mov Disord 2006;21:2052-2061.
  3. Elble RJ, Pullman SL, Matsumoto JY, Raethjen J, Deuschl G, Tintner R and the Tremor Research Group. Tremor amplitude is logarithmically related to 4- and 5-point tremor rating scales. Brain 2006; 129:2660-2666.
  4. Elble R, Comella C, Fahn S, Hallett M, Jankovic J, Juncos JL, LeWitt P, Lyons K, Ondo W, Pahwa R, Sethi K, Stover N, Tarsy D, Testa C, Tintner R, Watts R, Zesiewicz T. Reliability of a new scale for essential tremor. Mov Disord 2012;27:1567-1569.
  5. Elble RJ. The Essential Tremor Rating Assessment Scale. J Neurol Neuromed (2016) 1(4): 34-38
  6. Ondo W, Hashem V, LeWitt P, Pahwa R, Tarsy D, Shih L, Zesiewicz T, Elble R. Comparison of the Fahn-Tolosa-Marin Clinical Rating Scale and The Essential Tremor Rating Assessment Scale (TETRAS). Mov Disord Clin Practice. 2017 Nov 23;5(1):60-65. doi: 10.1002/mdc3.12560
  7. Ondo W, LeWitt P, Elias J. Incisionless Thalamotomy for Essential Tremor by MR-guided Focused Ultrasound – Randomized, Sham-controlled Trial (abstract) MDS 2014.
  8. Elble R, Bhargava P, Dhaka L, Jalan P, Kaul S, Pandav V, Lyons K, Ondo W, Pahwa R, Sethi K, Tarsy D, Tintner R. Reliability of the Essential Tremor Rating Assessment Scale in untrained neurology residents (abstract) AAN 2013
  9. Yeo C, Ondo W, Kuo S for the Tremor Research Group. Tremor Research Group Essential Tremor Rating Scale (TETRAS): Assessing Impact of Different Item Instructions. (abstract) AAN 2018